Evolutionary dynamics of 3D genome architecture following polyploidization in cotton

Abstract

多倍化的过程显著的增加了转录调控的复杂性，这也反应在更加复杂的染色质高级结构中。通过比较四倍体两个亚基因组与对应的二倍体基因组，发现在四倍体基因组中更有利于A/Bcompartments、TAD的形成。并且四倍体TAD的boundary区域更加偏向性的出现在开发染色质区域，伴随着染色质修饰因子。同时分析两个亚基因组之间的互作，揭示了同源基因在空间上的接近，可能与同源基因之间的协同表达有关。

result

• We next compared the organization of A/B compartments between genomes of diploids and the subgenomes of tetraploids the At subgenome has a larger proportion of sequences with changes of compartment status than the Dt subgenome during polyploidization.

• we compared their distribution in conserved TAD boundaries with non-conserved boundaries. Using boundaries in diploids as a reference, we found that DNase I sensitivity signals were significantly higher for conserved boundaries in both the At and Dt subgenomes of two tetraploids than for non-conserved boundaries

参考

https://www.nature.com/articles/s41477-017-0096-3